If you take a bath or a shower or use a sauna, apply topical estradiol after you have finished bathing, showering or using the sauna and have dried your skin completely. If you plan to swim, allow as much time as possible between applying estradiol gel and swimming. Do not apply sunscreen shortly before, at the same time, or soon after you apply topical estradiol. Estradiol gel may catch fire. When you apply estradiol gel, do not smoke or go near a fire or open flame until the gel dries.
Be careful not to get estradiol gel in your eyes. If you do get estradiol gel in your eyes, wash them with plenty of warm water right away. Call a doctor if your eyes become irritated. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine. If you forget to apply a dose of estradiol gel but remember more than 12 hours before you are scheduled to apply your next dose, apply the missed dose right away.
If you remember less than 12 hours before you are scheduled to apply your next dose, skip the missed dose and continue your regular dosing schedule the next day. Do not apply extra gel to make up for a missed dose. If you forget to apply estradiol emulsion in the morning, apply it as soon as you remember.
Do not apply extra emulsion to make up for a missed dose and do not apply estradiol emulsion more than once each day. Topical estradiol may increase your risk of developing cancer of the ovaries and gallbladder disease that may need to be treated with surgery. Talk to your doctor about the risks of using this medication. Topical estradiol may cause other side effects.
Call your doctor if you have any unusual problems while taking this medication. Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture not in the bathroom. Do not freeze topical estradiol. Keep estradiol gel away from open flame. Dispose of your estradiol gel pump after you have used 64 doses even if it is not completely empty.
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet.
Instead, the best way to dispose of your medication is through a medicine take-back program. It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location — one that is up and away and out of their sight and reach.
In case of overdose, call the poison control helpline at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at Keep all appointments with your doctor and the laboratory. The applicator is designed to help measure your prescribed dosage. Premarin Vaginal Cream uses a non-liquefying base. How much should I use? How often should I apply Premarin Vaginal Cream? To treat moderate to severe painful intercourse due to menopause, Premarin Vaginal Cream can be applied twice a week or in a cyclic regimen of 21 days on therapy, followed by 7 days off therapy, using a 0.
To treat vulvar and vaginal atrophy VVA , Premarin Vaginal Cream should be applied in a cyclic regimen of 21 days on therapy, followed by 7 days off therapy. Generally, women should be started at the 0. Dosage adjustments 0. You can apply the cream at any time of day that works for you in accordance with your prescribed treatment schedule. You may want to consider picking a time of day to apply Premarin Vaginal Cream and sticking to it.
For example, on the twice-a-week regimen, you might choose Monday and Thursday evenings, right before bed. How long until I start to feel a difference with painful intercourse?
Ordering Free Replacement Applicators. The tools to help you stick with your treatment plan. Call to order free applicators. Understanding associated risks.
Serious, but less common side effects include: Heart attack Stroke Blood clots Dementia Breast cancer Cancer of the lining of the uterus womb Cancer of the ovary High blood pressure High blood sugar Gallbladder disease Liver problems Enlargement of benign tumors of the uterus "fibroids" Severe allergic reaction. Call your healthcare provider right away if you get any of the following warning signs or any other unusual symptoms that concern you: New breast lumps Unusual vaginal bleeding Changes in vision or speech Sudden new severe headaches Severe pains in your chest or legs with or without shortness of breath, weakness, and fatigue Swollen lips, tongue, or face.
Less serious, but common side effects include: Headache Breast pain Irregular vaginal bleeding or spotting Stomach or abdominal cramps or bloating Nausea and vomiting Hair loss Fluid retention Vaginal yeast infection Reactions from inserting Premarin Vaginal Cream, such as vaginal burning, irritation, and itching.
Two options are Premarin cream and Estrace. Both are very well absorbed. Some women think that because you apply the cream only inside your vagina, none of it will get into the rest of your body. Some of the estrogen is absorbed into your blood. In fact, both Premarin and Estrace raise your blood levels of estrogen much the same as estrogen pills. You only need a low dose of these products. One study found that a dose of 0.
When you start using vaginal cream, you apply a small dab just inside your vagina daily for three or four weeks. Then you can reduce your use to once or twice a week.
If you apply it daily for more than four to six weeks, it becomes less effective. You should use K-Y Jelly or Astroglide or another type of lubricant before having sex. Easier and less messy are the new sustained release products, Estring and Vagifem. Estring is a low-dose estrogen ring that is placed in the vagina much like a diaphragm for three months at a time. Don't miss your FREE gift. Sign up to get tips for living a healthy lifestyle, with ways to fight inflammation and improve cognitive health , plus the latest advances in preventative medicine, diet and exercise , pain relief, blood pressure and cholesterol management, and more.
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